PUBLICATIONS

To find out more about our findings, please read our publications.

2026

γδ T cell-derived IL-4 initiates CD8⁺ T cell immunity. Nat Immunol.

Preclinical development of a cross-protective β-SARS-CoV-2 virus-like particle vaccine adjuvanted with MF59. NPJ Vaccines. 

Method for Determining the Affinity of the T Cell Receptor for the Peptide-Human Leukocyte Antigen Complex. Methods Mol Biol.

Method for Performing T Cell Receptor-Peptide-Human Leukocyte Antigen Co-complexation and Structural Analysis. Methods Mol Biol.

Method for Producing Recombinant Soluble T-Cell Receptors. Methods Mol Biol.

2025

An HLA Association With COVID-19 Vaccine Reactogenicity Correlates With Fewer SARS-CoV-2 Infections and Monocyte Activation. Res Sq [Preprint].

Antigen reactivity defines tissue-resident memory and exhausted T cells in tumors. Nat Immunol.

Endothelial cell-derived apoptotic bodies modulate innate and adaptive immune responses during inflammation. Cell Commun Signal.

Lack of immunogenicity for an influenza-derived peptide across the HLA-B44 supertype molecules. Clin Transl Immunology. 

Molecular basis of potent antiviral HLA-C-restricted CD8⁺ T cell response to an immunodominant SARS-CoV-2 nucleocapsid epitope. Nature Communications.

Antigen reactivity defines tissue-resident memory and exhausted T cells in tumours. BioRXiv (preprint).

Central memory T cells with key TCR repertoires and gene expression profiles dominate influenza CD8+ T cell pools across the human lifespan. PNAS.

Characterisation of an influenza B virus-derived peptide presented by HLA-B*18:01. Biochem J.

Long lived liver-resident memory T cells of biased specificities for abundant sporozoite antigens drive malaria protection by radiation-attenuated sporozoite vaccination. Plos Pathogens.

Gradual changes within long-lived influenza virus-specific CD8⁺ T cells are associated with the loss of public TCR clonotypes in older adults. Elife.

Mechanistic insight into the induction of liver tissue-resident memory CD8⁺ T cells by glycolipid-peptide vaccination. Cell Reports.

Molecular determinants of cross-strain influenza A virus recognition by αβ T cell receptors. Sci Immunol.

Measurement of serum 1,5-AG provides insights for diabetes management and the anti-viral immune response. Cell Mol Life Sci.

2024

Twelfth scientific biennial meeting of the Australasian Virology Society: AVS12 2024. J Virology.

Molecular determinants of cross-strain influenza A virus recognition by αβ T cell receptors. Science Immunology.

A blood-based mRNA signature distinguishes people with Long COVID from recovered individuals. Frontiers Immunology.

Molecular insights into the HLA-B35 molecules’ classification associated with HIV control. Immunology Cell Biology.

Type I interferons induce an epigenetically distinct memory B cell subset in chronic viral infection. Immunity.

Characterisation of novel influenza-derived HLA-B*18:01-restricted epitopes. Clin Transl Immunology.

A blood-based mRNA signature distinguishes people with Long COVID from recovered individuals. Frontiers in Immunology.

CD8⁺ T cell epitope conservation in emerging H5N1 viruses suggests global protection. Clin Transl Immunology.

High glycemic variability is associated with a reduced T cell cytokine response to influenza A virus. iScience.

Beyond acute infection: mechanisms underlying post-acute sequelae of COVID-19 (PASC). The Medical Journal of Australia.

Fighting flu: novel CD8⁺ T-cell targets are required for future influenza vaccines. Clin Transl Immunology.

SARS-CoV-2-specific CD8⁺ T cells from people with long COVID establish and maintain effector phenotype and key TCR signatures over 2 years. PNAS.

Public T cell clonotypes are selected in HLA-B^∗57:01⁺/HIV⁺ patients independently of the viral load. Cell Reports.

Detection of Lymphocytic Choriomeningitis Virus-Specific Memory B Cells Using Antigen Tetramers. Methods Mol Biol.

The impact of SARS-CoV-2 spike mutation on peptide presentation is HLA allomorph-specific. Current Research in Structural Biology. 

Increasing HbA1c is associated with reduced CD8⁺ T cell functionality in response to influenza virus in a TCR-dependent manner in individuals with diabetes mellitus. Cell Mol Life Sci.

2023

Elevated BMI reduces the humoral response to SARS-CoV-2 infection. Clin Transl Immunology.

Molecular insights into the HLA-B35 molecules’ classification associated with HIV control. Immunol Cell Biol.

Newborn and child-like molecular signatures in older adults stem from TCR shifts across human lifespan. Nature Immunology.

CD1 lipidomes reveal lipid-binding motifs and size-based antigen-display mechanisms. Cell.

Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities. Nature Immunology.

mRNA vaccine against malaria tailored for liver-resident memory T cells. Nature Immunology.

A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection. Nature.

2022

SARS-CoV-2-specific CD4⁺ and CD8⁺ T cell responses can originate from cross-reactive CMV-specific T cells. Elife.

Ablation of CD8⁺ T cell recognition of an immunodominant epitope in SARS-CoV-2 Omicron variants BA.1, BA.2 and BA.3. Nature Communications.

Homologous peptides derived from influenza A, B and C viruses induce variable CD8⁺ T cell responses with cross-reactive potential. Clin Transl Immunology (CTI).

Protective HLA-B57: T cell and natural killer cell recognition in HIV infection. Biochem Soc Trans.

Covalent TCR-peptide-MHC interactions induce T cell activation and redirect T cell fate in the thymus. Nature Communications. doi: 10.1038/s41467-022-32692-4.

Ablation of CD8+ T-cell recognition of an immunodominant epitope in SARS-CoV-2 Omicron. Research Square (preprint).

Protocol for generation of human peptide-specific primary CD8⁺ T cell lines. STAR Protoc.

Cutting Edge: Unconventional CD8⁺ T Cell Recognition of a Naturally Occurring HLA-A*02:01-Restricted 20mer Epitope. Journal of Immunology.

HLA-A*11:01-restricted CD8+ T cell immunity against influenza A and influenza B viruses in Indigenous and non-Indigenous people. PLoS Pathog.

Limited Recognition of Highly Conserved Regions of SARS-CoV-2. Microbiol Spectr.

2021

COVID-19 vaccine booster induces a strong CD8⁺ T cell response against Omicron variant epitopes in HLA-A*02:01⁺ individuals. bioRxiv (pre-print).

Low antigen abundance limits efficient T-cell recognition of highly conserved regions of SARS-CoV-2. bioRxiv.

The pockets guide to HLA class I molecules. Biochem Soc Trans.

Molecular Basis of a Dominant SARS-CoV-2 Spike-Derived Epitope Presented by HLA-A*02:01 Recognised by a Public TCR. Cells.

Protein purification and crystallization of HLA-A∗02:01 in complex with SARS-CoV-2 peptides. STAR Protoc.

The role of T-cell immunity in COVID-19 severity amongst people living with type II diabetes. FEBS J.

Canonical T cell receptor docking on peptide-MHC is essential for T cell signaling. Science.

CD8⁺ T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph. Nat Commun.

Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients. Nat Commun.

CD8⁺ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope cross-react with selective seasonal coronaviruses. Immunity.

The presentation of SARS-CoV-2 peptides by the common HLA-A^∗02:01 molecule. iScience.

2020

The Many Faces of CD4⁺ T Cells: Immunological and Structural Characteristics. Int J Mol Sci.

TCR Recognition of Peptide-MHC-I: Rule Makers and Breakers. Int J Mol Sci.

Overlapping Peptides Elicit Distinct CD8⁺ T Cell Responses following Influenza A Virus Infection. J Immunol.

Impact of HLA-DR Antigen Binding Cleft Rigidity on T Cell Recognition. Int J Mol Sci.

A Shared TCR Bias toward an Immunogenic EBV Epitope Dominates in HLA-B*07:02-Expressing Individuals. J Immunol.

HLA-B*27:05 alters immunodominance hierarchy of universal influenza-specific CD8+ T cells. PLoS Pathog.

https://pubmed.ncbi.nlm.nih.gov/32396839/A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver T_RM Cell-Mediated Immunity against Malaria in Mice. Cell Host Microbe.

The unconventional role of HLA-E: The road less traveled. Molecular Immunology.